InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lrrc4b

Summary

InnateDB Protein

IDBP-178745.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrrc4b

Protein Name

leucine rich repeat containing 4B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000053123

InnateDB Gene

IDBG-178743 (Lrrc4b)

Protein Structure

UniProt Annotation

Function

Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass membrane protein. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding

Biological Process

GO:0051965

positive regulation of synapse assembly

Cellular Component

GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0042734	presynaptic membrane
GO:0044300	cerebellar mossy fiber

Protein Structure and Domains

PDB ID

MGI:3027390

InterPro

IPR000372 Leucine-rich repeat-containing N-terminal
IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM