InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gna15

Summary

InnateDB Protein

IDBP-178748.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gna15

Protein Name

guanine nucleotide binding protein, alpha 15

Synonyms

G[a]15; Galpha15;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049175

InnateDB Gene

IDBG-178746 (Gna15)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed primarily in hematopoietic cells. Coexpressed with EDG6 at the same relative levels in all tissues examined, with the highest levels in adult spleen and lung. {ECO:0000269PubMed:12401211}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0046872	metal ion binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0060158	phospholipase C-activating dopamine receptor signaling pathway

Cellular Component

GO:0005834	heterotrimeric G-protein complex
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane

Protein Structure and Domains

PDB ID

MGI:95770

InterPro

IPR000654 G-protein alpha subunit, group Q
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR011025 G protein alpha subunit, helical insertion
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00503
PF00025

PRINTS

PR00442
PR00318
PR00328

PIRSF

SMART

SM00275

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt