Version 5.4
Mus musculus Protein: Toe1
Summary
InnateDB Protein IDBP-178758.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Toe1
Protein Name target of EGR1, member 1 (nuclear)
Synonyms 4930584N22Rik; 4933424D16Rik; AI413517;
Species Mus musculus
Ensembl Protein ENSMUSP00000030451
InnateDB Gene IDBG-178754 (Toe1)
Protein Structure
UniProt Annotation
Function Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1 (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Note=Localizes to nuclear speckles. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID MGI:1915526
InterPro IPR000571 Zinc finger, CCCH-type
IPR006941 Ribonuclease CAF1
IPR012337 Ribonuclease H-like domain
PFAM PF00642
PF04857
PRINTS
PIRSF
SMART SM00356
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D2E2
PhosphoSite PhosphoSite-Q9D2E2
TrEMBL
UniProt Splice Variant
Entrez Gene 68276
UniGene Mm.30534
RefSeq NP_080930
MGI ID
MGI Symbol Toe1
OMIM
CCDS CCDS18517
HPRD
IMGT
EMBL AK016889 AK019829 AK046576 AK082975 AK148609 BC023109
GenPept AAH23109 BAB30482 BAB31871 BAC32792 BAC38718 BAE28623

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca