Version 5.4
Mus musculus Protein: Josd2
Summary
InnateDB Protein IDBP-178793.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Josd2
Protein Name Josephin domain containing 2
Synonyms 1110007C05Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000048415
InnateDB Gene IDBG-178791 (Josd2)
Protein Structure
UniProt Annotation
Function Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
GO:0008242 omega peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0016579 protein deubiquitination
Cellular Component
GO:0005575 cellular_component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:1913374
InterPro IPR006155 Machado-Joseph disease protein MJD
PFAM PF02099
PRINTS PR01233
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CR30
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 66124
UniGene Mm.358691
RefSeq NP_079644
MGI ID
MGI Symbol Josd2
OMIM
CCDS CCDS21208
HPRD
IMGT
EMBL AK002872 AK003525
GenPept BAB22420 BAB22837

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca