InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hat1

Summary

InnateDB Protein

IDBP-178802.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hat1

Protein Name

histone aminotransferase 1

Synonyms

2410071B14Rik; AA536933; Hat-1; KAT1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028408

InnateDB Gene

IDBG-178800 (Hat1)

Protein Structure

UniProt Annotation

Function

Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004402	histone acetyltransferase activity

Biological Process

GO:0006348	chromatin silencing at telomere
GO:0007584	response to nutrient
GO:0016568	chromatin modification
GO:0016573	histone acetylation

Cellular Component

GO:0005634	nucleus
GO:0016363	nuclear matrix

Protein Structure and Domains

PDB ID

MGI:96013

InterPro

IPR016181 Acyl-CoA N-acyltransferase
IPR017380 Histone acetyltransferase type B, catalytic subunit
IPR019467 Histone acetyl transferase HAT1 N-terminal

PFAM

PF10394

PRINTS

PIRSF

PIRSF038084

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BY71