InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mutyh

Summary

InnateDB Protein

IDBP-178808.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mutyh

Protein Name

mutY homolog (E. coli)

Synonyms

5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb; Mutyhbeta; Mutyhc; Myh;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099760

InnateDB Gene

IDBG-178806 (Mutyh)

Protein Structure

UniProt Annotation

Function

Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2- OH-A DNA glycosylase activities (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0019104	DNA N-glycosylase activity
GO:0032407	MutSalpha complex binding
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0006281	DNA repair
GO:0006284	base-excision repair

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

MGI:1917853

InterPro

IPR003265 HhH-GPD domain
IPR003651 Endonuclease III-like, iron-sulphur cluster loop motif
IPR011257 DNA glycosylase
IPR015797 NUDIX hydrolase domain-like

PFAM

PF00730
PF10576

PRINTS

PIRSF

SMART

SM00478
SM00525

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99P21