InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Casp7

Summary

InnateDB Protein

IDBP-178815.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Casp7

Protein Name

caspase 7

Synonyms

AI314680; caspase-7; CMH-1; ICE-IAP3; mCASP-7; Mch3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026062

InnateDB Gene

IDBG-178813 (Casp7)

Protein Structure

UniProt Annotation

Function

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Overexpression promotes programmed cell death (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Highly expressed in heart, lung, liver and kidney. Low levels in spleen, skeletal muscle and testis. No expression in the brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004190	aspartic-type endopeptidase activity
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process

Biological Process

GO:0001836	release of cytochrome c from mitochondria
GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0007507	heart development
GO:0007568	aging
GO:0009411	response to UV
GO:0016485	protein processing
GO:0043525	positive regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0097194	execution phase of apoptosis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:109383

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR002138 Peptidase C14, caspase non-catalytic subunit p10
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core

PFAM

PF00656

PRINTS

PR00376

PIRSF

SMART

SM00115

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt