InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pik3r1

Summary

InnateDB Protein

IDBP-178872.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Pik3r1

Protein Name

phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)

Synonyms

p50alpha; p55alpha; p85alpha; PI3K;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047004

InnateDB Gene

IDBG-178868 (Pik3r1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 109 experimentally validated interaction(s) in this database.
They are also associated with 234 interaction(s) predicted by orthology.

Experimentally validated
Total	109 [view]
Protein-Protein	107 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	234 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016303	1-phosphatidylinositol-3-kinase activity
GO:0035014	phosphatidylinositol 3-kinase regulator activity

Biological Process

GO:0001953	negative regulation of cell-matrix adhesion
GO:0006468	protein phosphorylation
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0030183	B cell differentiation
GO:0030335	positive regulation of cell migration
GO:0032760	positive regulation of tumor necrosis factor production
GO:0034644	cellular response to UV
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
GO:0043066	negative regulation of apoptotic process
GO:0043551	regulation of phosphatidylinositol 3-kinase activity
GO:0045671	negative regulation of osteoclast differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051531	NFAT protein import into nucleus