Version 5.4
Mus musculus Protein: Reep4
Summary
InnateDB Protein IDBP-178901.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Reep4
Protein Name receptor accessory protein 4
Synonyms 2700029E10Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000040162
InnateDB Gene IDBG-178899 (Reep4)
Protein Structure
UniProt Annotation
Function Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0008017 microtubule binding
Biological Process
GO:0006998 nuclear envelope organization
GO:0007067 mitotic nuclear division
GO:0007084 mitotic nuclear envelope reassembly
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005874 microtubule
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1919799
InterPro IPR004345 TB2/DP1/HVA22-related protein
PFAM PF03134
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K072
PhosphoSite PhosphoSite-Q8K072
TrEMBL
UniProt Splice Variant
Entrez Gene 72549
UniGene Mm.475459
RefSeq NP_850919
MGI ID
MGI Symbol Reep4
OMIM
CCDS CCDS27256
HPRD
IMGT
EMBL AY562232 BC033929
GenPept AAH33929 AAT70677

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca