Version 5.4
Mus musculus Protein: Cxcl15
Summary
InnateDB Protein IDBP-178911.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cxcl15
Protein Name chemokine (C-X-C motif) ligand 15
Synonyms Il8; lungkine; Scyb15; weche;
Species Mus musculus
Ensembl Protein ENSMUSP00000031322
InnateDB Gene IDBG-178909 (Cxcl15)
Protein Structure
UniProt Annotation
Function Chemotactic for neutrophils. Involved in lung-specific neutrophil trafficking during normal and inflammatory conditions. {ECO:0000269PubMed:11207292}.
Subcellular Localization Secreted {ECO:0000269PubMed:10228029}.
Disease Associations
Tissue Specificity Expression restricted to the lung, produced by bronchoepithelial cells and is released into the airways. Expressed at low levels in fetal lung. {ECO:0000269PubMed:10228029, ECO:0000269PubMed:11207292}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008009 chemokine activity
Biological Process
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0030097 hemopoiesis
GO:0030593 neutrophil chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:1339941
InterPro IPR001089 CXC chemokine
IPR001811 Chemokine interleukin-8-like domain
PFAM PF00048
PRINTS PR00437
PIRSF
SMART SM00199
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WVL7
PhosphoSite PhosphoSite-Q9WVL7
TrEMBL
UniProt Splice Variant
Entrez Gene 20309
UniGene Mm.64326
RefSeq NP_035469
MGI ID
MGI Symbol Cxcl15
OMIM
CCDS CCDS19418
HPRD
IMGT
EMBL AF082859 AK142955 BC061138 CH466617
GenPept AAD38079 AAH61138 BAE25229 EDL05302

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca