Version 5.4
Mus musculus Protein: Cxcl1
Summary
InnateDB Protein IDBP-178945.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cxcl1
Protein Name chemokine (C-X-C motif) ligand 1
Synonyms Fsp; gro; Gro1; KC; Mgsa; N51; Scyb1;
Species Mus musculus
Ensembl Protein ENSMUSP00000031327
InnateDB Gene IDBG-178943 (Cxcl1)
Protein Structure
UniProt Annotation
Function Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation (By similarity). Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity. {ECO:0000250, ECO:0000269PubMed:10725737}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 6 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008009 chemokine activity
GO:0008083 growth factor activity
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0045087 innate immune response (InnateDB)
GO:0060326 cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:108068
InterPro IPR001089 CXC chemokine
IPR001811 Chemokine interleukin-8-like domain
PFAM PF00048
PRINTS PR00437
PIRSF
SMART SM00199
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P12850
PhosphoSite PhosphoSite-
TrEMBL Q5U5W9
UniProt Splice Variant
Entrez Gene 14825
UniGene Mm.407629
RefSeq NP_032202
MGI ID
MGI Symbol Cxcl1
OMIM
CCDS CCDS39143
HPRD
IMGT
EMBL BC037997 BC132502 BC132504 CH466617 J04596 S79767 U20527 U20634
GenPept AAA40131 AAB03376 AAH37997 AAI32503 AAI32505 EDL05301

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca