InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mthfd2l

Summary

InnateDB Protein

IDBP-178983.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mthfd2l

Protein Name

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000071578

InnateDB Gene

IDBG-178981 (Mthfd2l)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004477	methenyltetrahydrofolate cyclohydrolase activity
GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity
GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity

Biological Process

GO:0000105	histidine biosynthetic process
GO:0006164	purine nucleotide biosynthetic process
GO:0006730	one-carbon metabolic process
GO:0009086	methionine biosynthetic process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0035999	tetrahydrofolate interconversion
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane

Protein Structure and Domains

PDB ID

MGI:1915871

InterPro

IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase
IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain

PFAM

PF00763
PF02882

PRINTS

PR00085

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

D3YZG8