InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dlx2

Summary

InnateDB Protein

IDBP-178986.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dlx2

Protein Name

distal-less homeobox 2

Synonyms

AW121999; Dlx-2; Tes-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024159

InnateDB Gene

IDBG-178984 (Dlx2)

Protein Structure

UniProt Annotation

Function

Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed only in neural and other ectodermal structures of the head: the brain, the vomeronasal organ, and the preameloblasts of the teeth. Primarily expressed in the germinal cells of the ventral forebrain in the midgestational embryo, and in both dorsal and ventral ventricular zones in late embryogenesis and early postnatal life. {ECO:0000269PubMed:8098616}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003727	single-stranded RNA binding
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0009954	proximal/distal pattern formation
GO:0021544	subpallium development
GO:0021766	hippocampus development
GO:0021772	olfactory bulb development
GO:0021879	forebrain neuron differentiation
GO:0021882	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
GO:0021892	cerebral cortex GABAergic interneuron differentiation
GO:0021893	cerebral cortex GABAergic interneuron fate commitment
GO:0030154	cell differentiation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0045746	negative regulation of Notch signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048706	embryonic skeletal system development
GO:0048715	negative regulation of oligodendrocyte differentiation
GO:0048755	branching morphogenesis of a nerve
GO:0051216	cartilage development

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:94902

InterPro

IPR000047 Helix-turn-helix motif
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR020479 Homeodomain, metazoa
IPR022135 Distal-less-like homeobox protein, N-terminal domain

PFAM

PF00046
PF12413

PRINTS

PR00031
PR00024

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt