Version 5.4
Mus musculus Protein: Herc1
Summary
InnateDB Protein IDBP-179008.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Herc1
Protein Name hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000044801
InnateDB Gene IDBG-179002 (Herc1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016874 ligase activity
Biological Process
GO:0010507 negative regulation of autophagy
GO:0016567 protein ubiquitination
GO:0021702 cerebellar Purkinje cell differentiation
GO:0031175 neuron projection development
GO:0050885 neuromuscular process controlling balance
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID MGI:2384589
InterPro IPR000408 Regulator of chromosome condensation, RCC1
IPR000569 HECT
IPR001680 WD40 repeat
IPR001870 B30.2/SPRY domain
IPR003877 SPla/RYanodine receptor SPRY
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR009060 UBA-like
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
IPR017986 WD40-repeat-containing domain
IPR018355 SPla/RYanodine receptor subgroup
PFAM PF00415
PF00632
PF00400
PF00622
PRINTS PR00633
PIRSF
SMART SM00119
SM00320
SM00449
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-NP_663592
TrEMBL Q9CS23
UniProt Splice Variant
Entrez Gene 235439
UniGene Mm.482342
RefSeq NP_663592
MGI ID
MGI Symbol Herc1
OMIM
CCDS CCDS52840
HPRD
IMGT
EMBL AC161382 AC166755 AK019286 AK045649
GenPept BAB31647 BAC32444

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca