InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ier3

Summary

InnateDB Protein

IDBP-179066.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ier3

Protein Name

immediate early response 3

Synonyms

AI663993; cI-3; gly96; IEX-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003635

InnateDB Gene

IDBG-179064 (Ier3)

Protein Structure

UniProt Annotation

Function

May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A- PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias. {ECO:0000250, ECO:0000269PubMed:22565310}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed predominantly in the lung, testes and the uterus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001562	response to protozoan
GO:0003085	negative regulation of systemic arterial blood pressure
GO:0006282	regulation of DNA repair
GO:0007095	mitotic G2 DNA damage checkpoint
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0043066	negative regulation of apoptotic process
GO:0045732	positive regulation of protein catabolic process
GO:0045820	negative regulation of glycolytic process
GO:0046822	regulation of nucleocytoplasmic transport
GO:0050728	negative regulation of inflammatory response
GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:2000377	regulation of reactive oxygen species metabolic process
GO:2001020	regulation of response to DNA damage stimulus