InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hectd3

Summary

InnateDB Protein

IDBP-179077.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hectd3

Protein Name

HECT domain containing 3

Synonyms

1700064K09Rik; AI467540; AW743312;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000051922

InnateDB Gene

IDBG-179075 (Hectd3)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP (By imilarity). Mediates also ubiquitination of STX8. {ECO:0000269PubMed:18821010}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000269PubMed:18821010}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016874	ligase activity
GO:0019905	syntaxin binding

Biological Process

GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process

Cellular Component