Version 5.4
Mus musculus Protein: Tle6
Summary
InnateDB Protein IDBP-179106.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tle6
Protein Name transducin-like enhancer of split 6, homolog of Drosophila E(spl)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000071905
InnateDB Gene IDBG-179104 (Tle6)
Protein Structure
UniProt Annotation
Function As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions. {ECO:0000269PubMed:18804437}.
Subcellular Localization Cytoplasm. Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions.
Disease Associations
Tissue Specificity Expressed predominantly in ovaries, where it is restricted to growing oocytes, with greatest levels in fully grown oocytes (PubMed:18804437). Expressed predominantly in testis, heart, lung, liver and muscle, and at very low levels in the brain, spleen and kidney (PubMed:11486032). {ECO:0000269PubMed:11486032, ECO:0000269PubMed:18804437}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005938 cell cortex
GO:0043234 protein complex
Protein Structure and Domains
PDB ID MGI:2149593
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WVB3
PhosphoSite PhosphoSite-Q9WVB3
TrEMBL Q80XH3
UniProt Splice Variant
Entrez Gene 114606
UniGene Mm.488733
RefSeq NP_444484
MGI ID
MGI Symbol Tle6
OMIM
CCDS CCDS24064
HPRD
IMGT
EMBL AC153919 AF145957 BC048832 CH466553
GenPept AAD37693 AAH48832 EDL31392

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca