InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Timp4

Summary

InnateDB Protein

IDBP-179217.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Timp4

Protein Name

tissue inhibitor of metalloproteinase 4

Synonyms

TIMP-4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032462

InnateDB Gene

IDBG-179215 (Timp4)

Protein Structure

UniProt Annotation

Function

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in brain, heart, ovary and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008191	metalloendopeptidase inhibitor activity
GO:0046872	metal ion binding

Biological Process

GO:0007417	central nervous system development
GO:0009725	response to hormone
GO:0010951	negative regulation of endopeptidase activity
GO:0032496	response to lipopolysaccharide
GO:0034097	response to cytokine
GO:0042493	response to drug
GO:0042698	ovulation cycle
GO:0043434	response to peptide hormone

Cellular Component

GO:0005615	extracellular space
GO:0030017	sarcomere

Protein Structure and Domains

PDB ID

MGI:109125

InterPro

IPR001134 Netrin domain
IPR001820 Proteinase inhibitor I35, tissue inhibitor of metalloproteinase
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold

PFAM

PF00965

PRINTS

PIRSF

SMART

SM00206

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JHB3