InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Psmg1

Summary

InnateDB Protein

IDBP-179308.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psmg1

Protein Name

proteasome (prosome, macropain) assembly chaperone 1

Synonyms

AW552102; Dscr2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023630

InnateDB Gene

IDBG-179306 (Psmg1)

Protein Structure

UniProt Annotation

Function

Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (By similarity). {ECO:0000250UniProtKB:O95456}.

Subcellular Localization

Cytoplasm {ECO:0000250UniProtKB:O95456}. Endoplasmic reticulum {ECO:0000250UniProtKB:O95456}.

Disease Associations

Tissue Specificity

Highly expressed in testis with moderate expression in brain, liver and kidney and low levels in heart, skeletal muscle and pancreas. {ECO:0000269PubMed:10872820}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0070628	proteasome binding

Biological Process

GO:0021930	cerebellar granule cell precursor proliferation
GO:0043248	proteasome assembly
GO:0080129	proteasome core complex assembly

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum

Protein Structure and Domains

PDB ID

MGI:1860263

InterPro

IPR016565 Proteasome assembly chaperone 1

PFAM

PRINTS

PIRSF

PIRSF010076

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JK23

PhosphoSite

PhosphoSite-Q9JK23

TrEMBL

UniProt Splice Variant

Entrez Gene

56088

UniGene

Mm.473063

RefSeq

NP_062410

MGI ID

MGI Symbol

Psmg1

OMIM

CCDS

CCDS28352

HPRD

IMGT

EMBL

AJ238270 AK042203 AK088118 BC032965 BC060285

GenPept

AAH32965 AAH60285 BAC31197 BAC40157 CAB87195