InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Npm2

Summary

InnateDB Protein

IDBP-179378.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Npm2

Protein Name

nucleophosmin/nucleoplasmin 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000057365

InnateDB Gene

IDBG-179376 (Npm2)

Protein Structure

UniProt Annotation

Function

Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12714744}. Note=Found in the oocyte nucleus before nuclear membrane breakdown, after which it is redistributed to the cytoplasm.

Disease Associations

Tissue Specificity

Ovary specific. {ECO:0000269PubMed:12714744}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003682	chromatin binding
GO:0019899	enzyme binding

Biological Process

GO:0006338	chromatin remodeling
GO:0007096	regulation of exit from mitosis
GO:0007338	single fertilization
GO:0009790	embryo development
GO:0009994	oocyte differentiation
GO:0043085	positive regulation of catalytic activity
GO:0045740	positive regulation of DNA replication
GO:0045836	positive regulation of meiosis
GO:0051054	positive regulation of DNA metabolic process
GO:0051260	protein homooligomerization