InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myh14

Summary

InnateDB Protein

IDBP-179397.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myh14

Protein Name

myosin, heavy polypeptide 14

Synonyms

2400004E04Rik; II-C; NHMCII; NMHC II-C;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046059

InnateDB Gene

IDBG-179395 (Myh14)

Protein Structure

UniProt Annotation

Function

Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Highest levels in lung, kidney, brain and colon, very low levels in liver and bladder and no expression in spleen or seminal vesicle (at protein level). Isoform 1 is expressed in liver, kidney and testis with low levels in skeletal muscle and heart. Isoform 1 and isoform 2 are expressed in brain and lung. Isoform 2 is the main isoform expressed in skeletal muscle and heart. Isoform 3 is limited to brain stem, cerebellum and spinal cord. {ECO:0000269PubMed:14594953, ECO:0000269PubMed:19240025}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0030898	actin-dependent ATPase activity
GO:0051015	actin filament binding

Biological Process

GO:0006200	ATP catabolic process
GO:0008152	metabolic process
GO:0008360	regulation of cell shape
GO:0030048	actin filament-based movement

Cellular Component

GO:0001725	stress fiber
GO:0005737	cytoplasm
GO:0016459	myosin complex
GO:0030424	axon
GO:0030426	growth cone

Protein Structure and Domains

PDB ID

MGI:1919210

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001609 Myosin head, motor domain
IPR002928 Myosin tail
IPR004009 Myosin, N-terminal, SH3-like
IPR008989 Myosin S1 fragment, N-terminal
IPR009053 Prefoldin
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00063
PF01576
PF02736

PRINTS

PR00193

PIRSF

SMART

SM00015
SM00242

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt