InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plk3

Summary

InnateDB Protein

IDBP-179421.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plk3

Protein Name

polo-like kinase 3 (Drosophila)

Synonyms

Cnk; Fnk; PRK;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000076130

InnateDB Gene

IDBG-179419 (Plk3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000084	mitotic S phase
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000302	response to reactive oxygen species
GO:0006468	protein phosphorylation
GO:0006970	response to osmotic stress
GO:0006974	cellular response to DNA damage stimulus
GO:0009314	response to radiation
GO:0031122	cytoplasmic microtubule organization
GO:0043066	negative regulation of apoptotic process
GO:0051302	regulation of cell division
GO:0090166	Golgi disassembly
GO:0090316	positive regulation of intracellular protein transport
GO:2000777	positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005795	Golgi stack
GO:0005813	centrosome
GO:0030425	dendrite
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:109604

InterPro

IPR000719 Protein kinase domain
IPR000959 POLO box duplicated domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00659
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt