Version 5.4
Mus musculus Protein: Cand2
Summary
InnateDB Protein IDBP-179528.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cand2
Protein Name cullin-associated and neddylation-dissociated 2 (putative)
Synonyms 2210404G23Rik; mKIAA0667; Tp120b;
Species Mus musculus
Ensembl Protein ENSMUSP00000075377
InnateDB Gene IDBG-179526 (Cand2)
Protein Structure
UniProt Annotation
Function Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in embryonic limb buds. {ECO:0000269PubMed:12207886}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0017025 TBP-class protein binding
Biological Process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1914338
InterPro IPR000357 HEAT
IPR013932 TATA-binding protein interacting (TIP20)
IPR016024 Armadillo-type fold
PFAM PF02985
PF08623
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZQ73
PhosphoSite PhosphoSite-Q6ZQ73
TrEMBL Q3TD19
UniProt Splice Variant
Entrez Gene 67088
UniGene Mm.277683
RefSeq NP_080234
MGI ID
MGI Symbol Cand2
OMIM
CCDS CCDS20442
HPRD
IMGT
EMBL AK129186 AK170420 BC056365
GenPept AAH56365 BAC97996 BAE41786

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca