InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kif2c

Summary

InnateDB Protein

IDBP-179550.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kif2c

Protein Name

kinesin family member 2C

Synonyms

4930402F02Rik; ESTM5; Knsl6; MCAK; X83316;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000064261

InnateDB Gene

IDBG-179548 (Kif2c)

Protein Structure

UniProt Annotation

Function

In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Associates with the microtubule network at the growing distal tip (the plus- end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1. Association with microtubule plus ends is also mediated by interaction with KIF18B (By similarity). Centromeric localization requires the presence of BUB1 and SGOL2 (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0051010	microtubule plus-end binding

Biological Process

GO:0007018	microtubule-based movement
GO:0007019	microtubule depolymerization
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0008152	metabolic process
GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity
GO:0051983	regulation of chromosome segregation

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005871	kinesin complex
GO:0005881	cytoplasmic microtubule
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0035371	microtubule plus-end