InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fndc3a

Summary

InnateDB Protein

IDBP-179577.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fndc3a

Protein Name

fibronectin type III domain containing 3A

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000086411

InnateDB Gene

IDBG-179575 (Fndc3a)

Protein Structure

UniProt Annotation

Function

Mediates spermatid-Sertoli adhesion during spermatogenesis. {ECO:0000269PubMed:16904100}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Testis. Localizes to the acrosome of spermatids, as well as to Leydig cells. Can be detected on the acrosome beginning at steps 2-3 and continuing until step 12 of spermiogenesis. {ECO:0000269PubMed:16904100}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007286	spermatid development
GO:0009566	fertilization
GO:0016337	single organismal cell-cell adhesion
GO:0060009	Sertoli cell development

Cellular Component

GO:0000139	Golgi membrane
GO:0001669	acrosomal vesicle
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0012506	vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031410	cytoplasmic vesicle