Version 5.4
Mus musculus Protein: Zfp473
Summary
InnateDB Protein IDBP-179593.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zfp473
Protein Name zinc finger protein 473
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000051069
InnateDB Gene IDBG-179589 (Zfp473)
Protein Structure
UniProt Annotation
Function Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Note=Stable component of Cajal bodies (CBs). Colocalizes with SMN, coilin and U7 snRNA (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006398 histone mRNA 3'-end processing
Cellular Component
GO:0005622 intracellular
GO:0015030 Cajal body
Protein Structure and Domains
PDB ID MGI:2442697
InterPro IPR001909 Krueppel-associated box
IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF01352
PF00096
PRINTS
PIRSF
SMART SM00349
SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BI67
PhosphoSite PhosphoSite-
TrEMBL E9Q4I9
UniProt Splice Variant
Entrez Gene 243963
UniGene Mm.382935
RefSeq NP_848849
MGI ID
MGI Symbol Zfp473
OMIM
CCDS CCDS21213
HPRD
IMGT
EMBL AC150895 AK030093 AK036453 AK050747
GenPept BAC26780 BAC29437 BAC34403

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca