Version 5.4
| Mus musculus Protein: Arl4c | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-179607.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Arl4c | ||||||||
| Protein Name | ADP-ribosylation factor-like 4C | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000057085 | ||||||||
| InnateDB Gene | IDBG-179605 (Arl4c) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP- bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Cell projection, filopodium {ECO:0000250}. Cell membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2445172 | ||||||||
| InterPro |
IPR000795
Elongation factor, GTP-binding domain IPR001806 Small GTPase superfamily IPR003579 Small GTPase superfamily, Rab type IPR005225 Small GTP-binding protein domain IPR006687 Small GTPase superfamily, SAR1-type IPR006689 Small GTPase superfamily, ARF/SAR type IPR013684 Mitochondrial Rho-like IPR019009 Signal recognition particle receptor, beta subunit IPR024156 Small GTPase superfamily, ARF type IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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| PFAM |
PF00009
PF00071 PF00025 PF08477 PF09439 |
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| PRINTS |
PR00315
PR00449 PR00328 |
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| PIRSF | |||||||||
| SMART |
SM00175
SM00178 SM00177 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | P61208 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | Q810L2 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 320982 | ||||||||
| UniGene | Mm.477970 | ||||||||
| RefSeq | |||||||||
| MGI ID | |||||||||
| MGI Symbol | Arl4c | ||||||||
| OMIM | |||||||||
| CCDS | CCDS15146 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AJ623276 AK080335 AK080380 BC049804 BC055769 | ||||||||
| GenPept | AAH49804 AAH55769 BAC37882 BAC37900 CAF22225 | ||||||||