Version 5.4
Mus musculus Protein: Ptgfrn
Summary
InnateDB Protein IDBP-179625.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptgfrn
Protein Name prostaglandin F2 receptor negative regulator
Synonyms 4833445A08Rik; AU042434; CD9P-1; FPRP; Trim45;
Species Mus musculus
Ensembl Protein ENSMUSP00000099755
InnateDB Gene IDBG-179623 (Ptgfrn)
Protein Structure
UniProt Annotation
Function Inhibits the binding of prostaglandin F2-alpha (PGF2- alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0034389 lipid particle organization
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1277114
InterPro IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00406
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WV91
PhosphoSite PhosphoSite-Q9WV91
TrEMBL Q69ZJ6
UniProt Splice Variant
Entrez Gene 19221
UniGene Mm.24807
RefSeq NP_035327
MGI ID
MGI Symbol Ptgfrn
OMIM
CCDS CCDS17680
HPRD
IMGT
EMBL AF152344 AK173172 AL645930 AL669872 AL669937 AL672281 BC145713 BC145715
GenPept AAD38383 AAI45714 AAI45716 BAD32450 CAI26220 CAI26224 CAM22064

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca