InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fbxl22

Summary

InnateDB Protein

IDBP-179702.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxl22

Protein Name

F-box and leucine-rich repeat protein 22

Synonyms

1110004B15Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000060137

InnateDB Gene

IDBG-179700 (Fbxl22)

Protein Structure

UniProt Annotation

Function

Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC) (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269PubMed:22972877}.

Disease Associations

Tissue Specificity

Enriched in cardiac muscle (at protein level). {ECO:0000269PubMed:22972877}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0008150	biological_process
GO:0016567	protein ubiquitination

Cellular Component

GO:0005575	cellular_component
GO:0030018	Z disc

Protein Structure and Domains

PDB ID

MGI:1921415

InterPro

IPR001810 F-box domain
IPR006553 Leucine-rich repeat, cysteine-containing subtype

PFAM

PF00646
PF12937
PF13013

PRINTS

PIRSF

SMART

SM00256
SM00367

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8C7B6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

74165

UniGene

Mm.479391

RefSeq

NP_780415

MGI ID

MGI Symbol

Fbxl22

OMIM

CCDS

CCDS23304

HPRD

IMGT

EMBL

AK052175 AK084845 AK085980 BC100535

GenPept

AAI00536 BAC34870 BAC39291 BAC39583