InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rpgrip1l

Summary

InnateDB Protein

IDBP-179796.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rpgrip1l

Protein Name

Rpgrip1-like

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042702

InnateDB Gene

IDBG-179794 (Rpgrip1l)

Protein Structure

UniProt Annotation

Function

Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R) (By similarity). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left- right axis. Involved in the organization of apical junctions in kidney cells together with NPHP1 and NPHP4. Does not seem to be strictly required for ciliogenesis. {ECO:0000250, ECO:0000269PubMed:10501967, ECO:0000269PubMed:11956760, ECO:0000269PubMed:21565611}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Note=In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates to basolateral tight junctions. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Not found in heart and skin. {ECO:0000269PubMed:10501967}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	47 [view]
Protein-Protein	47 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0020037	heme binding
GO:0031870	thromboxane A2 receptor binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001822	kidney development
GO:0001889	liver development
GO:0007163	establishment or maintenance of cell polarity
GO:0007368	determination of left/right symmetry
GO:0007420	brain development
GO:0008589	regulation of smoothened signaling pathway
GO:0021532	neural tube patterning
GO:0021537	telencephalon development
GO:0021549	cerebellum development
GO:0021670	lateral ventricle development
GO:0021772	olfactory bulb development
GO:0022038	corpus callosum development
GO:0022900	electron transport chain
GO:0035108	limb morphogenesis
GO:0035115	embryonic forelimb morphogenesis
GO:0035116	embryonic hindlimb morphogenesis
GO:0042384	cilium assembly
GO:0043010	camera-type eye development
GO:0043584	nose development
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway
GO:0060039	pericardium development
GO:0060271	cilium morphogenesis
GO:0060322	head development

Cellular Component

GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0005929	cilium
GO:0005930	axoneme
GO:0036064	ciliary basal body