InnateDB Protein
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IDBP-179802.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Tbc1d17
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Protein Name
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TBC1 domain family, member 17
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000048260
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InnateDB Gene
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IDBG-179800 (Tbc1d17)
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Protein Structure
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Function |
Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasmic vesicle, autophagosome {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
22 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2449973
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InterPro |
IPR000195
Rab-GTPase-TBC domain
IPR021935
Domain of unknown function DUF3548
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PFAM |
PF00566
PF12068
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PRINTS |
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PIRSF |
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SMART |
SM00164
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BYH7
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PhosphoSite |
PhosphoSite-Q8BYH7
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TrEMBL |
Q8BW21
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UniProt Splice Variant |
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Entrez Gene |
233204
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UniGene |
Mm.27567
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RefSeq |
NP_001036120
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MGI ID |
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MGI Symbol |
Tbc1d17
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OMIM |
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CCDS |
CCDS39944
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HPRD |
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IMGT |
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EMBL |
AK039566
AK075571
AK136705
AK149917
AK170821
CH466603
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GenPept |
BAC30387
BAC35829
BAE23103
BAE29165
BAE42052
EDL22756
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