InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppwd1

Summary

InnateDB Protein

IDBP-179878.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppwd1

Protein Name

peptidylprolyl isomerase domain and WD repeat containing 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022226

InnateDB Gene

IDBG-179876 (Ppwd1)

Protein Structure

UniProt Annotation

Function

Putative peptidylprolyl isomerase (PPIase). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Associated with spliceosomal complexes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0006397	mRNA processing
GO:0006457	protein folding
GO:0008150	biological_process
GO:0008380	RNA splicing

Cellular Component

GO:0005634	nucleus
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

MGI:2443069

InterPro

IPR001680 WD40 repeat
IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
IPR017986 WD40-repeat-containing domain
IPR029000 Cyclophilin-like domain

PFAM

PF00400
PF00160

PRINTS

PR00153

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt