InnateDB Protein
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IDBP-179888.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Senp1
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Protein Name
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SUMO1/sentrin specific peptidase 1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000046598
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InnateDB Gene
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IDBG-179886 (Senp1)
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Protein Structure
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Function |
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. {ECO:0000269PubMed:15923632}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Shuttles between cytoplasm and nucleus. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
16 [view]
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Molecular Function |
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Biological Process |
GO:0006508
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proteolysis
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GO:0006919
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activation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0007275
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multicellular organismal development
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GO:0010724
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regulation of definitive erythrocyte differentiation
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GO:0016926
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protein desumoylation
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GO:0032435
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negative regulation of proteasomal ubiquitin-dependent protein catabolic process
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0097190
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apoptotic signaling pathway
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Cellular Component |
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PDB ID |
MGI:2445054
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InterPro |
IPR003653
Peptidase C48, SUMO/Sentrin/Ubl1
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PFAM |
PF02902
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P59110
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PhosphoSite |
PhosphoSite-P59110
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TrEMBL |
S4R1V9
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UniProt Splice Variant |
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Entrez Gene |
223870
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UniGene |
Mm.487443
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RefSeq |
NP_659100
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MGI ID |
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MGI Symbol |
Senp1
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OMIM |
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CCDS |
CCDS49717
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HPRD |
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IMGT |
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EMBL |
AC113444
AK028565
AK035581
AK088597
BC023129
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GenPept |
AAH23129
BAC26011
BAC29112
BAC40442
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