InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cxcl10

Summary

InnateDB Protein

IDBP-179918.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cxcl10

Protein Name

chemokine (C-X-C motif) ligand 10

Synonyms

C7; CRG-2; gIP-10; Ifi10; INP10; IP-10; IP10; mob-1; Scyb10;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047646

InnateDB Gene

IDBG-179916 (Cxcl10)

Protein Structure

UniProt Annotation

Function

In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in the spleen, thymus, lymph nodes and liver. {ECO:0000269PubMed:8145049}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	2 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008009	chemokine activity
GO:0008201	heparin binding
GO:0048248	CXCR3 chemokine receptor binding

Biological Process

GO:0002690	positive regulation of leukocyte chemotaxis
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0009306	protein secretion
GO:0009409	response to cold
GO:0009615	response to virus
GO:0010332	response to gamma radiation
GO:0010818	T cell chemotaxis
GO:0010996	response to auditory stimulus
GO:0016525	negative regulation of angiogenesis
GO:0030335	positive regulation of cell migration
GO:0030816	positive regulation of cAMP metabolic process
GO:0032496	response to lipopolysaccharide
GO:0033280	response to vitamin D
GO:0034605	cellular response to heat
GO:0042127	regulation of cell proliferation
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0045087	innate immune response (InnateDB)
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0051607	defense response to virus
GO:0060326	cell chemotaxis
GO:0070098	chemokine-mediated signaling pathway
GO:0071222	cellular response to lipopolysaccharide
GO:2000406	positive regulation of T cell migration