InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fto

Summary

InnateDB Protein

IDBP-179940.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fto

Protein Name

fat mass and obesity associated

Synonyms

AW743446; mKIAA1752;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000068380

InnateDB Gene

IDBG-179938 (Fto)

Protein Structure

UniProt Annotation

Function

Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Has no activity towards 1- methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation. {ECO:0000269PubMed:17991826, ECO:0000269PubMed:18775698, ECO:0000269PubMed:19234441, ECO:0000269PubMed:19680540}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17991826, ECO:0000269PubMed:19234441, ECO:0000269PubMed:19680540}. Nucleus speckle {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Detected in brain, brain cortex, hypothalamus, cerebellum, liver, pancreas, heart, kidney, white adipose tissue and skeletal muscle. Most abundant in the brain, particularly in hypothalamic nuclei governing energy balance. {ECO:0000269PubMed:17991826, ECO:0000269PubMed:19234441}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008198	ferrous iron binding
GO:0035515	oxidative RNA demethylase activity
GO:0035516	oxidative DNA demethylase activity
GO:0043734	DNA-N1-methyladenine dioxygenase activity

Biological Process

GO:0001659	temperature homeostasis
GO:0006307	DNA dealkylation involved in DNA repair
GO:0010883	regulation of lipid storage
GO:0035552	oxidative single-stranded DNA demethylation
GO:0035553	oxidative single-stranded RNA demethylation
GO:0040014	regulation of multicellular organism growth
GO:0042245	RNA repair
GO:0044065	regulation of respiratory system process
GO:0060612	adipose tissue development
GO:0070350	regulation of white fat cell proliferation
GO:0070989	oxidative demethylation
GO:0080111	DNA demethylation