InnateDB Protein
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IDBP-179954.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Chst11
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Protein Name
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carbohydrate sulfotransferase 11
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Synonyms
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1110020P09Rik; C4s; C4ST; C4ST-1; C4ST1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000045349
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InnateDB Gene
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IDBG-179952 (Chst11)
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Protein Structure
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Function |
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6- di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in brain and kidney. Also expressed at weaker level in heart, spleen and lung. Expressed in developing chondrocytes. {ECO:0000269PubMed:10722746}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0001537
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N-acetylgalactosamine 4-O-sulfotransferase activity
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GO:0008146
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sulfotransferase activity
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GO:0047756
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chondroitin 4-sulfotransferase activity
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GO:0050659
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N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1927166
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InterPro |
IPR005331
Sulfotransferase
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PFAM |
PF03567
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9JME2
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PhosphoSite |
PhosphoSite-Q9JME2
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TrEMBL |
B9EHC3
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UniProt Splice Variant |
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Entrez Gene |
58250
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UniGene |
Mm.395623
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RefSeq |
NP_067414
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MGI ID |
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MGI Symbol |
Chst11
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OMIM |
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CCDS |
CCDS24074
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HPRD |
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IMGT |
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EMBL |
AB030378
AJ289133
BC137629
CH466539
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GenPept |
AAI37630
BAA92942
CAB92141
EDL21380
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