InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Klf17

Summary

InnateDB Protein

IDBP-179960.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klf17

Protein Name

Kruppel-like factor 17

Synonyms

7420700M05Rik; AA420409; AU043468; C85123; D4Ertd561e; Gzf; Zfp393;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000052316

InnateDB Gene

IDBG-179958 (Klf17)

Protein Structure

UniProt Annotation

Function

Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development. {ECO:0000269PubMed:19801974}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Exclusively expressed in testis and ovary. Localized to step 3-8 spermatids in testis and growing oocytes in ovary. {ECO:0000269PubMed:12351194}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding