Version 5.4
Mus musculus Protein: Lpar6
Summary
InnateDB Protein IDBP-180008.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lpar6
Protein Name lysophosphatidic acid receptor 6
Synonyms 2610302I02Rik; P2ry5; P2y5;
Species Mus musculus
Ensembl Protein ENSMUSP00000042327
InnateDB Gene IDBG-180006 (Lpar6)
Protein Structure
UniProt Annotation
Function Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Ubiquitously expressed. Detected in the hair follicles and skin (at protein level). {ECO:0000269PubMed:18297070, ECO:0000269PubMed:18297072}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008150 biological_process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1914418
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BMC0
PhosphoSite PhosphoSite-Q8BMC0
TrEMBL
UniProt Splice Variant
Entrez Gene 67168
UniGene Mm.390681
RefSeq NP_780325
MGI ID
MGI Symbol Lpar6
OMIM
CCDS CCDS27268
HPRD
IMGT
EMBL AK032901 AK169602 BC047931 BC069991 BC145940 BC145942
GenPept AAH47931 AAH69991 AAI45941 AAI45943 BAC28077 BAE41252

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca