InnateDB Protein
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IDBP-180013.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cenpk
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Protein Name
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centromere protein K
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Synonyms
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B130045K24Rik; BB232189; C530004N04Rik; Cenp-K; Solt; Solzt;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000070910
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InnateDB Gene
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IDBG-180009 (Cenpk)
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Protein Structure
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Function |
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with CASC5/KNL1 to recruit the NDC80 complex to the outer kinetochore (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in testis. {ECO:0000269PubMed:10996314}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
MGI:1926210
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InterPro |
IPR020993
Centromere protein Cenp-K
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PFAM |
PF11802
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9ESN5
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
60411
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UniGene |
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RefSeq |
NP_851406
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MGI ID |
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MGI Symbol |
Cenpk
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OMIM |
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CCDS |
CCDS26750
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HPRD |
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IMGT |
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EMBL |
AB043687
AK082939
AK135773
BC092351
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GenPept |
AAH92351
BAB16367
BAC38702
BAE22654
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