Version 5.4
Mus musculus Protein: Cenpk
Summary
InnateDB Protein IDBP-180015.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cenpk
Protein Name centromere protein K
Synonyms B130045K24Rik; BB232189; C530004N04Rik; Cenp-K; Solt; Solzt;
Species Mus musculus
Ensembl Protein ENSMUSP00000022227
InnateDB Gene IDBG-180009 (Cenpk)
Protein Structure
UniProt Annotation
Function Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with CASC5/KNL1 to recruit the NDC80 complex to the outer kinetochore (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in testis. {ECO:0000269PubMed:10996314}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1926210
InterPro IPR020993 Centromere protein Cenp-K
PFAM PF11802
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ESN5
PhosphoSite PhosphoSite-NP_068562
TrEMBL
UniProt Splice Variant
Entrez Gene 60411
UniGene
RefSeq NP_068562
MGI ID
MGI Symbol Cenpk
OMIM
CCDS CCDS26749
HPRD
IMGT
EMBL AB043687 AK082939 AK135773 BC092351
GenPept AAH92351 BAB16367 BAC38702 BAE22654

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca