Version 5.4
Mus musculus Protein: Itgb2l
Summary
InnateDB Protein IDBP-180041.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Itgb2l
Protein Name integrin beta 2-like
Synonyms 5033406G21Rik; pactolus;
Species Mus musculus
Ensembl Protein ENSMUSP00000000161
InnateDB Gene IDBG-180039 (Itgb2l)
Protein Structure
UniProt Annotation
Function During inflammatory stimulation, plays a role in retaining Cxcl13-expressing cells at the site of the inflammatory response. {ECO:0000269PubMed:16836649}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:11461913, ECO:0000269PubMed:14662885, ECO:0000269PubMed:9535848}; Single- pass type I membrane protein {ECO:0000269PubMed:11461913, ECO:0000269PubMed:14662885, ECO:0000269PubMed:9535848}. Note=In unactivated neutrophils, the majority of the protein is contained in intracellular granules and is released to the cell surface following inflammatory activation or induction of necrotic or apoptotic cell death. {ECO:0000269PubMed:11461913, ECO:0000269PubMed:14662885, ECO:0000269PubMed:9535848}.
Disease Associations
Tissue Specificity Expressed predominantly in maturing and mature neutrophils. {ECO:0000269PubMed:11461913}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
Biological Process
GO:0006954 inflammatory response
GO:0007229 integrin-mediated signaling pathway
GO:0007275 multicellular organismal development
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1277979
InterPro IPR002035 von Willebrand factor, type A
IPR002369 Integrin beta subunit, N-terminal
IPR012896 Integrin beta subunit, tail
IPR013111 EGF-like domain, extracellular
IPR015812 Integrin beta subunit
IPR016201 Plexin-like fold
PFAM PF00092
PF00362
PF07965
PF07974
PRINTS PR01186
PIRSF PIRSF002512
SMART SM00327
SM00187
SM00423
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UV74
PhosphoSite PhosphoSite-Q3UV74
TrEMBL
UniProt Splice Variant
Entrez Gene 16415
UniGene Mm.12872
RefSeq NP_032431
MGI ID 2IUE
MGI Symbol Itgb2l
OMIM
CCDS CCDS28358
HPRD
IMGT
EMBL AF051367 AK137534 BC113142
GenPept AAC25502 AAI13143 BAE23399

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca