Version 5.4
Mus musculus Protein: Nudt15
Summary
InnateDB Protein IDBP-180108.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nudt15
Protein Name nudix (nucleoside diphosphate linked moiety X)-type motif 15
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000039537
InnateDB Gene IDBG-180106 (Nudt15)
Protein Structure
UniProt Annotation
Function Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear. May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA. {ECO:0000269PubMed:12767940}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0035539 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0000302 response to reactive oxygen species
GO:0006184 GTP catabolic process
GO:0006203 dGTP catabolic process
GO:0009217 purine deoxyribonucleoside triphosphate catabolic process
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID MGI:2443366
InterPro IPR000086 NUDIX hydrolase domain
IPR015797 NUDIX hydrolase domain-like
IPR020476 NUDIX hydrolase
PFAM PF00293
PRINTS PR00502
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BG93
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 214254
UniGene
RefSeq NP_766115
MGI ID
MGI Symbol Nudt15
OMIM
CCDS CCDS27270
HPRD
IMGT
EMBL AK032657 AK040749 BC060962
GenPept AAH60962 BAC27973 BAC30692

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca