InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Casq2

Summary

InnateDB Protein

IDBP-180169.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Casq2

Protein Name

calsequestrin 2

Synonyms

AA033488; AW146219; cCSQ; ESTM52;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029454

InnateDB Gene

IDBG-180167 (Casq2)

Protein Structure

UniProt Annotation

Function

Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+) ions (By similarity). {ECO:0000250}.

Subcellular Localization

Sarcoplasmic reticulum lumen. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells.

Disease Associations

Tissue Specificity

Heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0002027	regulation of heart rate
GO:0006937	regulation of muscle contraction
GO:0010649	regulation of cell communication by electrical coupling
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0043267	negative regulation of potassium ion transport
GO:0051208	sequestering of calcium ion
GO:0051258	protein polymerization
GO:0060048	cardiac muscle contraction
GO:0060306	regulation of membrane repolarization
GO:0071313	cellular response to caffeine
GO:1901017	negative regulation of potassium ion transmembrane transporter activity