InnateDB Protein
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IDBP-180188.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Wipf1
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Protein Name
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WAS/WASL interacting protein family, member 1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000099741
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InnateDB Gene
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IDBG-180182 (Wipf1)
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Protein Structure
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Function |
Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation (By similarity). Plays a role in the formation of cell ruffles. {ECO:0000250, ECO:0000269PubMed:12147689, ECO:0000269PubMed:19910490}.
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Subcellular Localization |
Cytoplasmic vesicle {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, ruffle {ECO:0000269PubMed:12147689, ECO:0000269PubMed:19910490}. Note=Vesicle surfaces and along actin tails. Colocalizes with actin stress fibers. When coexpressed with WASL, no longer associated with actin filaments but accumulated in perinuclear and cortical areas like WASL (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
19 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2178801
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InterPro |
IPR003124
WH2 domain
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PFAM |
PF02205
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PRINTS |
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PIRSF |
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SMART |
SM00246
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TIGRFAMs |
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Modification |
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SwissProt |
Q8K1I7
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PhosphoSite |
PhosphoSite-Q8K1I7
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TrEMBL |
Q3THY1
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UniProt Splice Variant |
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Entrez Gene |
215280
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UniGene |
Mm.475230
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RefSeq |
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MGI ID |
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MGI Symbol |
Wipf1
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OMIM |
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CCDS |
CCDS16131
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HPRD |
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IMGT |
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EMBL |
AJ437262
AK031046
AK156547
AK168092
AL928813
AL954713
BC049788
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GenPept |
AAH49788
BAC27228
BAE33753
BAE40065
CAD24773
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