Version 5.4
Mus musculus Protein: Wipf1
Summary
InnateDB Protein IDBP-180190.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wipf1
Protein Name WAS/WASL interacting protein family, member 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000099740
InnateDB Gene IDBG-180182 (Wipf1)
Protein Structure
UniProt Annotation
Function Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation (By similarity). Plays a role in the formation of cell ruffles. {ECO:0000250, ECO:0000269PubMed:12147689, ECO:0000269PubMed:19910490}.
Subcellular Localization Cytoplasmic vesicle {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, ruffle {ECO:0000269PubMed:12147689, ECO:0000269PubMed:19910490}. Note=Vesicle surfaces and along actin tails. Colocalizes with actin stress fibers. When coexpressed with WASL, no longer associated with actin filaments but accumulated in perinuclear and cortical areas like WASL (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0008154 actin polymerization or depolymerization
GO:0030048 actin filament-based movement
GO:0051707 response to other organism
Cellular Component
GO:0001726 ruffle
GO:0005884 actin filament
GO:0015629 actin cytoskeleton
GO:0016023 cytoplasmic membrane-bounded vesicle
Protein Structure and Domains
PDB ID MGI:2178801
InterPro IPR003124 WH2 domain
PFAM PF02205
PRINTS
PIRSF
SMART SM00246
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K1I7
PhosphoSite PhosphoSite-Q8K1I7
TrEMBL Q3THY1
UniProt Splice Variant
Entrez Gene 215280
UniGene Mm.475230
RefSeq
MGI ID
MGI Symbol Wipf1
OMIM
CCDS CCDS16131
HPRD
IMGT
EMBL AJ437262 AK031046 AK156547 AK168092 AL928813 AL954713 BC049788
GenPept AAH49788 BAC27228 BAE33753 BAE40065 CAD24773

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca