InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dph2

Summary

InnateDB Protein

IDBP-180223.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dph2

Protein Name

DPH2 homolog (S. cerevisiae)

Synonyms

9130020C19Rik; AI467389; Dph2l2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030265

InnateDB Gene

IDBG-180221 (Dph2)

Protein Structure

UniProt Annotation

Function

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). {ECO:0000269PubMed:15485916}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0017183

peptidyl-diphthamide biosynthetic process from peptidyl-histidine

Cellular Component

GO:0005575	cellular_component
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1914978

InterPro

IPR002728 Diphthamide synthesis, DPH1/DPH2
IPR010014 Diphthamide synthesis DHP2, eukaryotic

PFAM

PF01866

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CR25

PhosphoSite

PhosphoSite-Q9CR25

TrEMBL

UniProt Splice Variant

Entrez Gene

67728

UniGene

Mm.396654

RefSeq

NP_080620

MGI ID

MGI Symbol

Dph2

OMIM

CCDS

CCDS18541

HPRD

IMGT

EMBL

AK011199 AK018638 AL627128 BC031124

GenPept

AAH31124 BAB27462 BAB31322 CAM14719