InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mlph

Summary

InnateDB Protein

IDBP-180249.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mlph

Protein Name

melanophilin

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027528

InnateDB Gene

IDBG-180247 (Mlph)

Protein Structure

UniProt Annotation

Function

Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269PubMed:11504925, ECO:0000269PubMed:11887186}.

Subcellular Localization

Melanosome.

Disease Associations

Tissue Specificity

Highly expressed in embryos at day 7; not detectable at day 11. Highly expressed in adult stomach; detected at lower levels in kidney, lung, skin and small intestine. Detected in melanocytes. {ECO:0000269PubMed:11504925}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0017022	myosin binding
GO:0017137	Rab GTPase binding
GO:0031489	myosin V binding
GO:0046872	metal ion binding
GO:0051010	microtubule plus-end binding

Biological Process

GO:0006605	protein targeting
GO:0006886	intracellular protein transport
GO:0030318	melanocyte differentiation
GO:0032400	melanosome localization
GO:0043473	pigmentation

Cellular Component

GO:0001725	stress fiber
GO:0005815	microtubule organizing center
GO:0015629	actin cytoskeleton
GO:0030864	cortical actin cytoskeleton
GO:0035371	microtubule plus-end
GO:0042470	melanosome