Mus musculus Protein: Bace2 | |||||||||||
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Summary | |||||||||||
InnateDB Protein | IDBP-180273.6 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | Bace2 | ||||||||||
Protein Name | beta-site APP-cleaving enzyme 2 | ||||||||||
Synonyms | 1110059C24Rik; AEPLC; AI850424; ALP56; ARP1; ASP21; BAE2; CDA13; CEAP1; DRAP; | ||||||||||
Species | Mus musculus | ||||||||||
Ensembl Protein | ENSMUSP00000043918 | ||||||||||
InnateDB Gene | IDBG-180271 (Bace2) | ||||||||||
Protein Structure | |||||||||||
UniProt Annotation | |||||||||||
Function | Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672 (By similarity). {ECO:0000250}. | ||||||||||
Subcellular Localization | Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Endosome {ECO:0000250}. Cell surface {ECO:0000250}. | ||||||||||
Disease Associations | |||||||||||
Tissue Specificity | |||||||||||
Comments | |||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||
PDB ID | MGI:1860440 | ||||||||||
InterPro |
IPR001461
Aspartic peptidase IPR009119 Peptidase A1, beta-site APP cleaving enzyme, BACE IPR009120 Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1 IPR009121 Peptidase A1, beta-site APP cleaving enzyme 2, BACE 2 IPR021109 Aspartic peptidase domain |
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PFAM |
PF00026
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PRINTS |
PR00792
PR01815 PR01816 PR01817 |
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PIRSF | |||||||||||
SMART | |||||||||||
TIGRFAMs | |||||||||||
Post-translational Modifications | |||||||||||
Modification | |||||||||||
Cross-References | |||||||||||
SwissProt | Q9JL18 | ||||||||||
PhosphoSite | PhosphoSite-Q9JL18 | ||||||||||
TrEMBL | |||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 56175 | ||||||||||
UniGene | Mm.97885 | ||||||||||
RefSeq | NP_062390 | ||||||||||
MGI ID | |||||||||||
MGI Symbol | Bace2 | ||||||||||
OMIM | |||||||||||
CCDS | CCDS28359 | ||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | AF051150 AF216310 AK052309 AK078770 AK165036 BC120773 BC131947 CH466602 | ||||||||||
GenPept | AAD45964 AAF36599 AAI20774 AAI31948 BAC34931 BAC37384 BAE38011 EDL03663 | ||||||||||