InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lpcat2

Summary

InnateDB Protein

IDBP-180296.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lpcat2

Protein Name

lysophosphatidylcholine acyltransferase 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049252

InnateDB Gene

IDBG-180294 (Lpcat2)

Protein Structure

UniProt Annotation

Function

Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet- activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso- PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3- phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2- diacyl-sn-glycero-3-phosphocholine. {ECO:0000269PubMed:17182612, ECO:0000269PubMed:18156367}.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Lipid droplet {ECO:0000250}.

Disease Associations

Tissue Specificity

Highest expression is found in resident macrophages and casein-induced neutrophils followed by skin, colon, spleen and thioglycollate-induced macrophages. Detected in erythroleukemic cells but not in reticulocytes. {ECO:0000269PubMed:17182612, ECO:0000269PubMed:18156367}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0005509	calcium ion binding
GO:0016746	transferase activity, transferring acyl groups
GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity
GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity

Biological Process

GO:0006663	platelet activating factor biosynthetic process
GO:0008152	metabolic process
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0061024	membrane organization

Cellular Component

GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005795	Golgi stack
GO:0005811	lipid particle
GO:0016021	integral component of membrane