Version 5.4
Mus musculus Protein: Appl2
Summary
InnateDB Protein IDBP-180305.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Appl2
Protein Name adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000020500
InnateDB Gene IDBG-180303 (Appl2)
Protein Structure
UniProt Annotation
Function Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction (By similarity). {ECO:0000250}.
Subcellular Localization Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007049 cell cycle
GO:0008283 cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0010008 endosome membrane
GO:0016581 NuRD complex
GO:0031901 early endosome membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2384914
InterPro IPR001849 Pleckstrin homology domain
IPR006020 PTB/PI domain
IPR013625 Tensin phosphotyrosine-binding domain
PFAM PF00169
PF00640
PF14719
PF08416
PRINTS
PIRSF
SMART SM00233
SM00462
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K3G9
PhosphoSite PhosphoSite-Q8K3G9
TrEMBL Q3TVI6
UniProt Splice Variant
Entrez Gene 216190
UniGene Mm.282985
RefSeq NP_660255
MGI ID
MGI Symbol Appl2
OMIM
CCDS CCDS24078
HPRD
IMGT
EMBL AK160075 AK160105 AY113706 BC002232 BC048906 CH466539
GenPept AAH02232 AAH48906 AAM55532 BAE35609 BAE35632 EDL21394

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca